From Tpr-Met to Met, tumorigenesis and tubes
نویسندگان
چکیده
منابع مشابه
Novel interaction partners of the TPR/MET tyrosine kinase.
A large variety of biological processes is mediated by stimulation of the receptor tyrosine kinase MET. Screening a mouse embryo cDNA library, we were able to identify several novel, putative intracellular TPR/MET-substrates: SNAPIN, DCOHM, VAV-1, Sorting nexin 2, Death associated protein kinase 3, SMC-1, Centromeric protein C, and hTID-1. Interactions as identified by yeast two-hybrid analysis...
متن کاملA novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase.
The Met receptor tyrosine kinase has been shown to be overexpressed or mutated in a variety of solid tumors and has, therefore, been identified as a good candidate for molecularly targeted therapy. Activation of the Met tyrosine kinase by the TPR gene was originally described in vitro through carcinogen-induced rearrangement. The TPR-MET fusion protein contains constitutively elevated Met tyros...
متن کاملCRL's Approach to MET
From February to April CRL carried out investigations into the modification of our l~n~Hsh name recognition software developed for MUC-6 [1] to Chinese and Spanish. In addition a Japanese system, developed under Tipster Phase I [2], was modified to comply with the MET task. Finally learning methods developed for MUC-6 were adapted to handle Chinese. All systems performed with good levels of acc...
متن کاملThe TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions.
The TPR-MET oncogenic rearrangement was originally observed in an in vitro transformed human osteosarcoma cell line. Recently, we detected the expression of this rearrangement at very low levels in several cell lines derived from human tumors of nonhematopoietic origin using a highly sensitive method based on polymerase chain reaction amplification of the transcript. We report here the results ...
متن کاملPathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein.
The Tpr-Met oncoprotein, which is a member of a family of tyrosine kinase oncoproteins generated following genomic rearrangement, consists of the catalytic kinase domain of the hepatocyte growth factor/scatter factor receptor tyrosine kinase (Met) fused downstream from sequences encoded by the tpr gene. We have previously demonstrated that a single tyrosine residue in the carboxyl terminus, Tyr...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2007
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1210201